Yannick Nlandu1*, François Lepira1, Jean-Robert Makulo1, Yannick Engole1, Ernest Sumaili1, Marie-Noelle Wameso1,
Vieux Mokoli1, Jeannine Luse2, Augustin Longo1, Chantal Zinga1, Pierre Akilimali3, Aliocha Nkodila1,
Mélanie Bavassa4, François Kajingulu1, Justine Bukabau1 and Nazaire Nseka1


Abstract

Background: Stroke is the third leading cause of cardiovascular mortality in dialysis patients. The objective of this study was to assess the extent of stroke in chronic hemodialysis patients.

Methods : Historical cohort of patients enrolled in two hemodialysis (HD) centers from January 1, 2010 to December 31, 2011, including 191 patients (mean age 52 years, 68% men). Incidence curves and survival time analysis between the first day of HD and the end of the study were described by the Kaplan-Meier method.
Independent stroke predictors were identified by multiple logistic regression analysis. P < 0.05 defined the level of statistical significance.

Results : 12 incident stroke were recorded during the study period, with 1622.1 person-months (PM), a stroke incidence rate of 7.4 cases per 1000 PM (95% CI = 7.35–7.44) at the point date. The incidence of stroke at 6 months, 12 months and 24 months was 9.8%, 11.9% and 13%, respectively. Only the absence of arterial hypertension (RR = 5.7, 95% CI: 1.52–21.42) emerged as an independent determinant of stroke.

Conclusion : The high incidence of stroke in Kinshasa HD centers is partially explained by reverse epidemiology.
Efforts must be made to understand this phenomenon in order to reduce its impact.

Keywords : Stroke, Hemodialysis, Incidence, Reverse epidemiology, Black people


Nlandu et al. BMC Nephrology (2017) 18:277
DOI 10.1186/s12882-017-0697-0