B. C. Mpembe1, F. B. Lepira2*, F. I. Mbutiwi2, J. R. Makulo2, E. V. Kintoki1, M. P. Bayauli3,
J. R. M’Buyamba-Kabangu1
1Division of Cardiology and Hypertension, Kinshasa School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
2Division of Nephrology, Kinshasa School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
3Division of Endocrinology and Metabolic Diseases, Kinshasa School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of the Congo
Email: *lepslepira@yahoo.fr
World Journal of Cardiovascular Diseases
Abstract
Objective: To assess the LV mass, geometry and systolic function in hypertensive patients with reduced kidney function. Methods: According to ASE guidelines, we estimated LV ventricular mass, geometry and systolic function in 155 consecutive hypertensive patients [51% women, mean age
51 ± 12 years, median duration of hypertension 7 years] with reduced kidney function (eGFR < 60 ml/min/1.73 m2 or dipstick proteinuria ≥ 1+). LVH was defined as LVMI >125 g/m2 in men, >110 g/m2 in non obese women or >51 g/m2.7 for obese men or women. Where appropriate, we used
Student t, Mann Whitney, one way ANOVA or Chi square tests. A P value of 0.05 or less was considered significant. Results: Seventy four patients in the series (48%) had reduced kidney function (eGFR 30 ± 15 ml/min/1.73 m2). Compared to patients with relatively normal kidney function, non
obese and obese patients with reduced kidney function had significantly greater LVM [271 (198 -348) vs 276 (175 – 284) g/m2, p = 0.008] for non obese; LVM 72 (47 – 88) vs 54 (44 – 73) g/m2.7, p =0.007 for obese] and lower EF (60 ± 14 vs 6 8 ± 1 3%, p < 0 .001) w as s ignificantly l ower. L VH o f mainly concentric geometric pattern was present in 68 patients with reduced kidney function (92%). Conclusion: In the present case series, reduced kidney function was associated with increased LVM, concentric geometric pattern and impaired systolic function.
Keywords
Echocardiographic-LVH, Reduced Kidney Function, Hypertension, Black Africans